XlinkCyNET

XlinkCyNET is an open-source Java plugin that generates residue-to-residue connections provided by XL-MS in protein interaction networks. It provides an interactive interface for the exploration of cross-links and offers various options to display protein domains. XlinkCyNET works well in complex networks containing thousands of proteins.

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Features

  • Visualize protein-protein interaction network based on cross-linking mass spectrometry data

  • Apply residue-to-residue connection layout to Cytoscape interaction network

  • Annotate protein domains of all proteins in the network

  • Map cross-links on high-resolution structures through PyMOL

Downloads

  • https://apps.cytoscape.org/apps/xlinkcynet

Tutorial